BPN 0026709 - CAS 2404652-24-8

BPN 0026709 (MT-228) is a selective, blood-brain barrier-permeable non-muscle myosin II inhibitor. BPN 0026709 demonstrates enhanced tolerability by preferentially targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), with SmMll MD sharing 83.6% sequence identity with NMllB. BPN 0026709 exhibits sustained efficacy in animal models of stimulant use disorder.

Others, Myosin

Cytoskeletal Signaling, Others

2404620

>99.99%

C19H19N3O3

337.37

O[C@]12C(N(CC1)C=3C=C(OC)N=CC3)=NC=4C(C2=O)=CC(C)=C(C)C4

-20°C

Ice Packs

Small Compound