BPU17 - CAS 2198977-68-1

BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs) . BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD) .

Others, Mitochondrial Metabolism

Others, Metabolism

2198908

C12H13ClN2O2

252.7

O=C(NC1=CC=C(Cl)C=C1)NC(=O)C2CCC2

-20°C

Ice Packs

Small Compound