Bractoppin - CAS 2290527-07-8

Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t) BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

2290527-07-8

0.9965

C25H23FN4O

414.47

Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1

-20°C

Ice Packs

Small Compound