BRD-810 - CAS 2329719-65-3

BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, suitable for studying haematological malignancies and solid tumours. BRD-810 binds the BH3 groove of MCL1, activates Caspase, and disrupts the MCL1-BAK complex in cancer cells (IC50=1.2 nM) .

Caspase, Bcl-2 Family, Apoptosis

Proteases/Proteasome, Apoptosis

2329719-65-3

0.9788

C39H44ClFN4O5

703.24

ClC1=C2C3=C(C(CCCOC=4C5=C(C=CC4)C=C(F)C=C5)=C(C(O)=O)N3CCCCO[C@H](CCN6CCOCC6)C=7C2=C(CC)N(C)N7)C=C1

-20°C

Ice Packs

Small Compound