BRD-K20733377 - CAS 452350-43-5

BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.

Bcl-2 Family

Apoptosis

452302

C23H18N4O3S

430.48

O=C(NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CC=N2)C=3C=CC(=CC3)C=4C=CC=CC4

-20°C

Ice Packs

Small Compound