BRD PHOTAC-I-3 - CAS 2370997-94-5

BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera) . BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+) -JQ1. Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark.

Others

Others

2370898

C46H47ClN10O8S

935.45

COc1cc(cc(OC)c1OCC(=O)NCCCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)\N=N\c1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O |c:25|

-20°C

Ice Packs

Small Compound