BRD4 degrader-2 - CAS 3036530-43-2

BRD4 degrader-2 (Compound JP-2-197) is a covalent and monovalent molecule glue-type BRD4 degrader. It targets RNF126 (E3 ligase) to degrade both long and short isoforms of BRD4 in cells.

Molecular Glues, Epigenetic Reader Domain, E1/E2/E3 Enzyme

Chromatin/Epigenetic, PROTAC, Ubiquitination

3036485

C34H33ClN6O4S

657.18

CC=1C2=C(N3C([C@H](CC(=O)N4CCN(C(/C=C/C(=O)C5=CC=C(OC)C=C5)=O)CC4)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C

-20°C

Ice Packs

PROTAC