BRD4 Inhibitor-28 - CAS 2468960-80-5

BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55 nM, respectively. It also demonstrates inhibition of BRD2-BD1, BRD3-BD1, and BRDT-BD1 with IC50 values of 19, 25, and 68 nM, respectively. Furthermore, this compound exhibits anti-melanoma activity [1].

Epigenetic Reader Domain

Chromatin/Epigenetic

2468875

C23H21N3O3

387.43

C(N1C=2C=3N(C1=O)CCOC3C=C(C2)C=4C=C(C)C(=O)N(C)C4)C5=CC=CC=C5

-20°C

Ice Packs

Small Compound