BRD4/NAMPT-IN-1 - CAS 3049218-28-9

BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4) . This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity.

Epigenetic Reader Domain, NAMPT

Metabolism, Chromatin/Epigenetic

3049181

C30H30ClN7O2S

588.12

CC=1C2=C(N3C([C@H](CC(NCCCNC(/C=C/C=4C=CC=NC4)=O)=O)N=C2C5=CC=C(Cl)C=C5)=NN=C3C)SC1C

-20°C

Ice Packs

Small Compound