Brevetoxin B - CAS 79580-28-2

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Others, Sodium Channel

Membrane transporter/Ion channel, Others

79550

C50H70O14

895.096

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-20°C

Ice Packs

Natural Product