BRF110 - CAS 2095489-35-1

BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1) :Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.

Retinoid Receptor, NR4A, Others

Endocrinology/Hormones, Metabolism, Others

2095453

C22H18F3N3O2

413.39

C(C=C)C=1C(N(C)C2=CC=C(C(O)=O)C=C2)=NC(=NC1C(F)(F)F)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound