Britannilactone diacetate - CAS 1286694-67-4

1,6-O, O-Diacetylbritannilactone (OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.

ROS, JAK, MAPK, JNK, STAT, IL Receptor, Caspase, PARP, NO Synthase

Tyrosine Kinase/Adaptors, DNA Damage/DNA Repair, Immunology/Inflammation, JAK/STAT signaling, Proteases/Proteasome, Stem Cells, Chromatin/Epigenetic, Apoptosis, Angiogenesis, MAPK

1286623

C19H26O6

350.41

C[C@@H](CCCOC(C)=O)C1=C(C)C[C@H]2OC(=O)C(=C)[C@H]2[C@@H]1OC(C)=O

-20°C

Ice Packs

Natural Product