Bromfenac sodium hydrate - CAS 120638-55-3

Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP) .

COX

Neuroscience, Immunology/Inflammation

120580

0.9965

C15H12BrNO3·3/2H2O·Na

383.17

O.[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c1ccc(Br)cc1

-20°C

Ice Packs

Small Compound