Broussochalcone A - CAS 99217-68-2

Broussochalcone A is a natural antioxidant and xanthine oxidase inhibitor (IC50 = 2.21 μM) that scavenges free radicals, inhibits iron-induced lipid peroxidation, and reduces nitric oxide synthesis in LPS-activated macrophages. Broussochalcone A induces apoptosis in human renal carcinoma cells by increasing ROS levels and activating the FOXO3 signaling pathway. Broussochalcone A is also a novel NR4A1 inhibitor that induces apoptosis in pancreatic cancer cells through NR4A1-dependent pathways.

Reactive Oxygen Species, Apoptosis, NR4A, FOXO, ROS, Xanthine Oxidase

NF-κB, Apoptosis, Endocrinology/Hormones, Immunology/Inflammation, Metabolism

99147

0.9746

C20H20O5

340.37

C(/C=C/C1=CC(O)=C(O)C=C1)(=O)C2=CC(CC=C(C)C)=C(O)C=C2O

-20°C

Ice Packs

Natural Product