Broussonin A - CAS 73731-87-0

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay; it suppresses lipopolysaccharide (LPS) -stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-ÎoB and down-regulation of the Akt and ERK signaling pathways.

NOS, Akt, IκB/IKK, Cholinesterase (ChE), NF-κB, IL Receptor, ERK

Neuroscience, NF-κB, MAPK, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Immunology/Inflammation

73644

C16H18O3

258.317

COc1ccc(CCCc2ccc(O)cc2)c(O)c1

-20°C

Ice Packs

Natural Product