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Molfinity

BS-181 dihydrochloride - CAS 1883548-83-1

BS-181 dihydrochloride - CAS 1883548-83-1

MF-0045043-01

$797.63 USD
$797.63 USD
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Product Details

  • Bioactivity

    BS-181 dihydrochloride is a selective and potent inhibitor of CDK7 with an IC50 value of 21 nM. BS-181 dihydrochloride inhibits CDK2 (IC50: 880 nM), CDK5 (IC50: 3000 nM) and CDK9 (IC50: 4200 nM), but does not block CDK1, 4 and 6. BS-181 dihydrochloride inhibits the growth of a group of cancer cells (IC50: 11.5 μM-37.3 μM) and induces apoptosis.

  • Target

    Others, CDK

  • Related Pathways

    Cell Cycle/Checkpoint, Others

  • CAS Number

    1883464

  • Molecular Formula

    C22H34Cl2N6

  • Molecular Weight

    453.46

  • SMILES

    Cl.Cl.CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound