BSJ-4-116 - CAS 2519823-34-6

BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly (adenylation) .

PROTACs, CDK

Cell Cycle/Checkpoint, PROTAC

2519783

0.9909

C40H49ClN8O8S

837.38

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCN4C[C@H](NC=5N=C(NC6=C(S(C(C)C)(=O)=O)C=CC=C6)C(Cl)=CN5)CCC4)=O

-20°C

Ice Packs

PROTAC