BSJ-5-63 - CAS 2519823-37-9

BSJ-5-63 is an effective degrader of CDK12, CDK7, and CDK9. It reduces the protein expression of CDK12, CDK7, CDK9, RNAPII, and Cyclin K, and also decreases the mRNA expression of BRCA1 and BRCA2. BSJ-5-63 exhibits anticancer activity and holds potential for prostate cancer research.

CDK, PROTACs

Cell Cycle/Checkpoint, PROTAC

2519823-37-9

C52H74ClN9O6S2

1020.78

C([C@@H](NC(CCCCCCCCCCN1C[C@H](NC=2N=C(NC3=C(S(C(C)C)(=O)=O)C=CC=C3)C(Cl)=CN2)CCC1)=O)[C@](C)(C)C)(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4

-20°C

Ice Packs

Small Compound