Buclizine dihydrochloride - CAS 129-74-8

Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine dihydrochloride exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS) . This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.

Histamine Receptor, 5-HT Receptor, AChR

Immunology/Inflammation, Neuroscience, GPCR/G Protein

47

0.9956

C28H33ClN2·2HCl

505.95

CC(C)(C)c1ccc(cc1)CN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)Cl.Cl.Cl

-20°C

Ice Packs

Small Compound