Busulfan - CAS 55-98-1

Busulfan is an alkylating antineoplastic agent derived from dimethane sulfonate, with cytotoxic and immunosuppressive properties. It primarily acts by forming carbonium ions in vivo, which induce cross-linking between DNA strands or between DNA and proteins, leading to DNA damage, inhibition of DNA replication, and suppression of RNA transcription. In addition, Busulfan can inhibit thioredoxin reductase and induce apoptosis. It is commonly used as a myeloablative agent in preconditioning regimens for bone marrow transplantation and can also be used to establish anemia models.

DNA Alkylation, DNA Alkylator/Crosslinker, Apoptosis

Apoptosis, DNA Damage/DNA Repair

-44

0.9989

C6H14O6S2

246.3

CS(=O)(=O)OCCCCOS(C)(=O)=O

-20°C

Ice Packs

Small Compound