Butyzamide - CAS 1110767-45-7

Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.

STAT, JAK, p38 MAPK, Thrombopoietin Receptor

Chromatin/Epigenetic, JAK/STAT signaling, MAPK, Stem Cells, Immunology/Inflammation, Angiogenesis, Tyrosine Kinase/Adaptors

1110715

>99.99%

C29H32Cl2N2O5S

591.55

O(C)C1=C(C=CC=C1C(OCCC)C(C)(C)C)C=2N=C(NC(=O)C3=CC(Cl)=C(/C=C(/C(O)=O)\C)C(Cl)=C3)SC2

-20°C

Ice Packs

Small Compound