BVB-808 - CAS 1180158-99-9

BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning into therapeutic strategies for treatment of chronic myelogenous leukemia (CML) .

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1180050

C28H32F2N8O

534.6

N(C=1N=C2N(C=CC2=CN1)C3=CC(F)=C(CN4CCOCC4)C(F)=C3)C=5C=CC(=NC5)N6C[C@@H](C)N[C@@H](C)C6

-20°C

Ice Packs

Small Compound