BX795 - CAS 702675-74-9

BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than GSK3β.

C-Kit, PDK, Autophagy, IκB/IKK, Chk, CDK

Autophagy, NF-κB, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors

702592

0.9957

C23H26IN7O2S

591.47

Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c1cccs1

-20°C

Ice Packs

Small Compound