C-Met-IN-14 - CAS 2443380-34-3

C-Met-IN-14, a N-sulfonylamidine-based derivative, is a selective c-Met kinase inhibitor with an IC50 value of 2.89 nM. It exhibits anticancer properties by inhibiting c-Met phosphorylation and arresting the cell cycle at the G2/M phase. Additionally, c-Met-IN-14 promotes dose-dependent apoptosis in A549 cells.

C-Met/HGFR, Apoptosis, FLT, Others, c-Kit

Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, Others

2443343

C34H38ClFN4O7S

701.2

O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(N=C(NS(CC5=CC=C(Cl)C=C5)(=O)=O)CCOC)C=C4

-20°C

Ice Packs

Small Compound