C14-490 - CAS 2639634-82-3

C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs) . These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F (ab’) 2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs) .

Liposome

Metabolism

2639634-82-3

C86H177N5O7

1393.35

OC(CN(CCN1CCN(CC1)CC(OCC)CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(OCC)CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCCCCCCCCCCC

-20°C

Ice Packs

Inhibitors & Agonists