C188 - CAS 823828-18-8

C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation.

Others, Apoptosis, STAT

Apoptosis, Others, Stem Cells, JAK/STAT signaling

823802

C19H15NO7S2

433.45

OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O

-20°C

Ice Packs

Small Compound