C1s-IN-1 trihydrochloride - CAS 1376162-36-5

C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.

Complement System

Immunology/Inflammation

1376121

C16H22Cl3N5

390.74

N=C(C1=CN=C(N2CCN(CC2)C3=CC=CC=C3)C=C1)N.Cl.Cl.Cl

-20°C

Ice Packs

Small Compound