C82 - CAS 691862-35-8

C82 acts as an inhibitor of Mycobacterium tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP), with an IC50 value of 17.5 μM. This particular enzyme is responsible for breaking down cyclic di-AMP (c-di-AMP) into adenosine 5'-monophosphate (AMP) . Notably, C82 demonstrates selectivity for Mtb CdnP over other bacterial cyclic dinucleotide phosphodiesterases (CDN PDEs) such as Yybt, RocR, and Group B Streptococcus (GBS) CdnP, as well as the mammalian CDN PDE ENPP1, and the viral CDN PDE poxin, showing effectiveness at a concentration of 200 μM.

Others, PDE

Metabolism, Others

691862-35-8

C17H17N3O3S

343.4

O=C1C2=C(SC(CC)=C2)N=CN1CC(NC3=C(OC)C=CC=C3)=O

-20°C

Ice Packs

Small Compound