Caffeic Acid Phenethyl Ester - CAS 104594-70-9

Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF) -1alpha and subsequent induction of heme oxygenase-1 (HO-1) .

Apoptosis, NF-κB

Apoptosis, NF-κB

104515

0.9993

C17H16O4

284.31

Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O

-20°C

Ice Packs

Natural Product