CALP1 - CAS 145224-99-3

Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM) . Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.

CaMK, Apoptosis, PDE, GluR

Metabolism, Apoptosis, Neuroscience

145122

C40H75N9O10

842.09

[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)[C@@H](C)C)=O)CC(C)C)=O)[C@H](C)C)=O)[C@@H](C)O)=O)(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)[C@H](CC)C

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