Candidusin A - CAS 81474-59-1

Candidusin A (CHNQD-0803) (Compound 4) is an AMPK activator with a KD of 47.28 nM. This compound can be isolated from the marine fungus Aspergillus candidus. Candidusin A exhibits cytotoxic activity against human prostate cancer cells (22Rv1, PC-3, and LNCaP cells) and induces apoptosis. It reduces lipogenic gene expression and fat deposition, downregulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and improves liver injury and fibrosis. Candidusin A is applicable in the study of non-alcoholic steatohepatitis (NASH) .

NF-κB, Apoptosis, AMPK, TNF

PI3K/Akt/mTOR signaling, NF-κB, Apoptosis, Chromatin/Epigenetic

81474-59-1

C20H16O6

352.34

OC=1C=CC(=CC1)C2=CC(OC)=C3C(OC4=CC(O)=C(O)C=C43)=C2OC

-20°C

Ice Packs

Natural Product