Canfosfamide - CAS 158382-37-7

Canfosfamide (TLK-286, TER286), a glutathione analogue prodrug, becomes activated by glutathione S-transferase P1-1 to induce apoptosis and inhibit DNA-dependent protein kinase's (DNA-PK) catalytic kinase activity. Upon activation, it generates an anticancer alkylating agent and a glutathione derivative, making it useful in researching malignancies [1] [2] [3].

Others, Apoptosis, DNA-PK

Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Others

158338

C26H40Cl4N5O10PS

787.47

P(N(CCCl)CCCl)(N(CCCl)CCCl)(OCCS(C[C@@H](C(N[C@@H](C(O)=O)C1=CC=CC=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)(=O)=O)=O

-20°C

Ice Packs

Small Compound