CAR-2 - CAS 3030055-40-1

CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD) . It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.

Reactive Oxygen Species, Ferroptosis, Photosensitizer

NF-κB, Apoptosis, Metabolism, Immunology/Inflammation

3030014

C27H23BF2I2N4O2

738.114

O=C(OC)C=1N=C(C2=C3C(=C(I)C(=[N]3[B+3]([F-])([F-])[N-]4C2=C(C(I)=C4C)C)C)C)C5=C(C1)C=6C=CC=CC6N5C

-20°C

Ice Packs

Small Compound