β-Carboline-1-carboxylic acid - CAS 26052-96-0

β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 μg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 μg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 μg/ml, respectively) . It also inhibits cAMP phosphodiesterase with an IC50 value of 96 μM.

IDO, Indoleamine 2,3-Dioxygenase (IDO), NF-κB, Others, PDE, Antibacterial

Metabolism, Others, NF-κB, Microbiology/Virology

25956

C12H8N2O2

212.2

OC(=O)c1nccc2c3ccccc3[nH]c12

-20°C

Ice Packs

Small Compound