CAY10410 - CAS 596104-94-8

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α, β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.

Others, PPAR

Others, Metabolism, DNA Damage/DNA Repair

596002

C20H30O3

318.45

C(\C=C/CCCCC)=C/1\[C@@H](C/C=C\CCCC(O)=O)CCC1=O

-20°C

Ice Packs

Small Compound