CAY10416 - CAS 443919-96-8

Dual cyclooxygenase-2 (COX-2) /5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 μM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 μM.

Others, Lipoxygenase, COX

Immunology/Inflammation, Metabolism, Others, Neuroscience

443815

C29H29FN2O5S

536.61

O(C)C1(CCOCC1)C2=CC(OCC3=NN(C(=C3)C4=CC=CC=C4)C5=CC=C(S(C)(=O)=O)C=C5)=CC(F)=C2

-20°C

Ice Packs

Small Compound