CAY10443 - CAS 582314-48-5

Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 μM. These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.

Apoptosis, Caspase, PARP, Others, Mitochondrial Metabolism, DNA/RNA Synthesis

Others, Cell Cycle/Checkpoint, Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, Metabolism, DNA Damage/DNA Repair

582261

C17H15Cl2NO2

336.21

O(C(NCC1=CC(Cl)=C(Cl)C=C1)=O)[C@@H]2C=3C(CC2)=CC=CC3

-20°C

Ice Packs

Small Compound