CAY10508 - CAS 878533-35-8

CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 μM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.

Others, Cannabinoid Receptor

Others, GPCR/G Protein

878533-35-8

C21H14Br2N2O2

486.2

O=C1C(N(C(=O)N1C2=CC=C(Br)C=C2)C3=CC=C(Br)C=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound