CAY10535 - CAS 945716-28-9

TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2) . Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ (IC50 = 99 nM) relative to TPα (IC50 = 1,970 nM) in the inhibition of U46619-mediated Ca2+ mobilization. This compound exhibits relatively poor activity on platelets (IC50 = 985 nM) when inhibiting U-46619-induced platelet aggregation.

Others, Prostaglandin Receptor

Others, Immunology/Inflammation, GPCR/G Protein

945679

C18H21N3O7S

423.44

O(C1=C(S(NC(NC(C)(C)C)=O)(=O)=O)C=C(N(=O)=O)C=C1)C2=CC(OC)=CC=C2

-20°C

Ice Packs

Small Compound