CAY10568 - CAS 22913-17-3

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.

Sodium Channel, Others

Others, Membrane transporter/Ion channel

22893

C11H17IN2O

320.174

[I-].C[N+](C)(C)CC(=O)Nc1ccccc1

-20°C

Ice Packs

Small Compound