CAY10573 - CAS 853652-40-1

The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively. CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM) .

PPAR, Others

Others, DNA Damage/DNA Repair, Metabolism

853611

C33H31NO5

521.6

C(CC)C=1C2=C(C=C(C(=O)C3=CC=CC=C3)C=C2)C=CC1OCCCOC=4C=C5C(=CC4)N(CC(O)=O)C=C5

-20°C

Ice Packs

Small Compound