CAY10608 - CAS 457897-92-6

N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM) . It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.

Others, Potassium Channel, iGluR

Others, Membrane transporter/Ion channel, Neuroscience

457799

C18H22Cl2N2O4S

433.35

N(S(C)(=O)=O)C1=CC=C(OC[C@H](CNCCC2=CC(Cl)=C(Cl)C=C2)O)C=C1

-20°C

Ice Packs

Small Compound