CAY10681 - CAS 1542066-69-2

Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-κB signaling. It potently binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53. CAY10681 also inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65. It blocks the proliferation of cancer cell lines (IC50s range from 33 to 37 μM) . CAY10681 exhibits excellent oral bioavailability and inhibits tumor growth in A549 xenografts in nude mice.

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Others

1541995

C30H26BrN5O

552.46

C(CCN1C=CN=C1)N2C(C3=C(N(CC4=CC=CC=C4)N=C3C5=CC=CC=C5)C2=O)C6=CC=C(Br)C=C6

-20°C

Ice Packs

Small Compound