CAY10701 - CAS 1616967-52-2

CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively) . It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells. CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.

Microtubule Associated, Others

Cytoskeletal Signaling, Others

1616913

C24H19N3O2

381.43

C(=O)(C1=C(C2=C(N1)NC(CCCC#C)=NC2=O)C3=CC=CC=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound