CAY10721 - CAS 848688-62-0

CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM) . Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.

Others, Sirtuin

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

848626

C18H13N3O3S

351.38

OC1=CC(NC(=O)CSC2=NC=NC3=C2OC2=C3C=CC=C2)=CC=C1

-20°C

Ice Packs

Small Compound