CAY10722 - CAS 388086-13-3

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM) . SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.

Others, Sirtuin

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

388070

C21H14Cl2N2O2

397.25

ClC1=CC(Cl)=C(C=C1)C1=NC2=C(O1)C=CC(NC(=O)CC1=CC=CC=C1)=C2

-20°C

Ice Packs

Small Compound