CAY10744 - CAS 2375613-31-1

CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively) . CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.

Topoisomerase, Others

Others, DNA Damage/DNA Repair

2375581

C24H16ClNO2

385.84

OC1=C2CC=3C(C2=CC=C1)=NC(=CC3C4=CC=C(O)C=C4)C5=C(Cl)C=CC=C5

-20°C

Ice Packs

Small Compound