CAY10760 - CAS 391889-85-3

CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA) .1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib .

DNA/RNA Synthesis, Others

Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

391801

C28H24ClN3O3

485.96

CCC(=O)N1N=C(CC1C1=CC=C(OC)C=C1)C1=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2

-20°C

Ice Packs

Small Compound