CAY10773 - CAS 1648546-79-5

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM) . CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours.

Others, Autophagy, Ferroptosis, Apoptosis

Others, Apoptosis, Autophagy

1648462

C22H17Cl2N5O

438.31

N(CC1=CC(NC(NC2=CC(Cl)=C(Cl)C=C2)=O)=CC=C1)C=3C4=C(N=CN3)C=CC=C4

-20°C

Ice Packs

Small Compound