Caylin-2 - CAS 1392830-09-9

Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells. The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated.

MDM-2/p53, Others

Apoptosis, Others

1392830-09-9

C32H30F6N4O4

648.6

C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(C(F)(F)F)C=C3)C4=CC=C(C(F)(F)F)C=C4)N5CC(=O)NCC5

-20°C

Ice Packs

Small Compound